Complex tissue engineering and disease modeling
With the rapid development of biofabrication, stem cell, and tissue engineering technology, it is possible to reconstruct complex tissues and organs with bionic structure and function in vitro, which has significant scientific value and application potential in the regeneration and repair of diseased tissues, human disease research, and drug development. In recent years, our group has made remarkable achievements in vascularized myocardial tissue/myocardial compartment/bone tissue regeneration and repair through technological innovations such as decellularized matrix materials, precise regulation of stem cells, microgel biphasic bioink, stepwise suspension printing, and multifunctional bioreactor design. Through the integration of micro-nano manufacturing, bioprinting, organ chip, and other technologies, a series of works have been carried out in the in vitro pathological models such as blood-brain barrier and pulmonary fibrosis.
In vitro tumor models
In vitro tumor models are important tools in cancer research, providing insight into the molecular mechanisms of tumor growth and metastasis, and enabling the development of drug screening and cancer therapies. Traditional model systems such as 2D cell lines and animal models lack the three-dimensional complex structure and microenvironment of human tumors, which seriously hinder research efficiency. The construction of in vitro tumor models with tumor microenvironments is the key to cancer research and the clinical transformation of anti-cancer compounds. Advanced biomanufacturing technologies such as 3D bio-printing, droplet microfluidics, and organ chips could be used to carry out three-dimensional controlled assembly of personalized tumor cells, tumor microenvironment cells, and extracellular matrix components, so as to realize the accurate and rapid construction of in vitro biomimetic tumor models. These models have important transformation and application values in the field of basic research and drug development.
3D Bioprinting in Space
3D Bioprinting in Space is a new method that uses CAD models as ‘blueprints’ to assemble special ‘biological inks’ to produce artificial organs and biomedical products in space. 3D Bioprinting in Space is of great significance for manufacturing human organs and tissues for use in space or returning to the earth. It is also important technical support for space medical engineering and space biology research such as space composite effect assessment, space pharmacy, and space tumor treatment.
DNA data storage
The exponential growth of the world's total data volume poses a great challenge to traditional storage media. A new generation of high-density digital storage devices has been stimulated by the advent of molecular digital storage devices. DNA, in particular, is an ideal representative for molecular digital storage media due to its high storage density and long-term restoration time. As DNA synthesis and sequencing technologies progress and the cost decreases, DNA storage is attracting increasing attention and making significant breakthroughs. Our team hopes to achieve effective information storage of DNA by studying various aspects of DNA information storage.